New features in 2.0-beta:

  • Expanded detection rules from 6 to 12
  • Updated ClusterBlast database with 382 NCBI plant genomes
  • Detection of repeats in BURP domains (cyclopeptide BGCs)
  • Substrate prediction for various enzyme subfamilies

Supported Cluster Types (version 2.0-beta)#

Rule Min. Generic Domains* Special Domains Required
alkaloid 3 Bet_v_1, Cu_amine_oxid, Str_synth, BBE, Orn_DAP_Arg_deC, Pyridoxal_deC
fatty_acid 3 FA_desaturase, FA_desaturase_2, FA_hydroxylase, CER1-like_C, Transferase, ECH_2, AMP-binding
lignan 3 Dirigent
MatE 3 MatE
phenolamide 2 Transferase, Pyridoxal_deC, Orn_DAP_Arg_deC, Orn_Arg_deC_N
plant 4 None
polyketide 3 Chal_sti_synt_C, Chal_sti_synt_N, AMP-binding, Thr_dehydrat_C
saccharide 3 Glycos_transf_1, Glycos_transf_2, Glycos_transf_28, UDPGT, UDPGT_2, Glyco_hydro_1, Cellulose_synt
sesterterpene 2 Terpene_synth_C, polyprenyl_synt
strictosidine_like 2 Str_synth, Pyridoxal_deC
terpene 3 Terpene_synth, Terpene_synth_C, Prenyltrans, SQHop_cyclase_C, SQHop_cyclase_N, PRISE

* Generic domains:
Orn_DAP_Arg_deC, Pyridoxal_deC, BBE, FA_hydroxylase, CER1-like_C, ECH_2, Oxidored_FMN, 3Beta_HSD, Glyco_hydro_1, ADH_N, ADH_N_2, Abhydrolase_3, Aldo_ket_red, cMT, nMT, oMT, adh_short, Chal_sti_synt_C, Chal_sti_synt_N, COesterase, UDPGT, Glyco_transf_28, Glycos_transf_1, Glycos_transf_2, Lycopene_cycl, NAD_binding_1, p450, SQHop_cyclase_C, SQHop_cyclase_N, Prenyltrans, Terpene_synth_C, Terpene_synth, Transferase, Aminotran_1_2, AMP-binding, DIOX_N, Dirigent, Bet_v_1, Cu_amine_oxid, Str_synth, Trp_syntA, His_biosynth, adh_short_C2, Peptidase_S10, Prenyltransf, Epimerase, 2OG-FeII_Oxy, Aminotran_3, Methyltransf_2, Methyltransf_3, Methyltransf_7, PRISE, Cellulose_synt, Chalcone, ERG4_ERG24, FA_desaturase, FA_desaturase_2, Methyltransf_11, polyprenyl_synt, SE, SQS_PSY, TPMT, UbiA, Lipoxygenase, Lyase_aromatic, HMGL-like, Chalcone_3, Chalcone_2, Acetyltransf_1, UDPGT_2, GMC_oxred_N, GMC_oxred_C, Amino_oxidase, DAHP_synth_1, DAHP_synth_2

  • Note that sesterpene, strictosidine-like, phenolamide and cyclopeptide also use MatE as a generic domain.